All three antiviral agents are generally well tolerated. The amount of acyclovir that you take depends on the strength of acyclovir. Objective: Acyclovir prophylaxis has been considered as mandatory for patients receiving bortezomib because herpes zoster is a common adverse event associated with the use of bortezomib. Bean B, Aeppli D, Balfour HH Jr. Acyclovir given intravenously in either low dose (5 mg/kg every 8 h) or high dose (500 mg/m2 every 8 h) significantly reduced pain and accelerated skin healing in acute herpes zoster occurring in otherwise healthy adults. Although the minimal effective dose of acyclovir for prophylaxis has not yet established, the efficacy of low-dose acyclovir prophylaxis, 400 mg once daily, has been suggested. Several antiviral medicines—acyclovir, valacyclovir, and famciclovir—are available to treat shingles and shorten the length and severity of the illness. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Find a list of current medications, their possible side effects, dosage, and efficacy when used to treat or reduce the symptoms of shingles The recommended dosages for acyclovir, famciclovir and valacyclovir are provided in Table 1. The higher dose also significantly reduced the duration of viral shedding. List of references (click here) Zovirax Capsule, Tablet, and Suspension [package insert]. Shingles Home > Acyclovir Dosing. Valaciclovir, the l-valyl ester of acyclovir, is rapidly and almost completely converted to acyclovir in vivo and gives three- to fivefold increases in acyclovir bioavailability. Acyclovir in shingles. Acyclovir dosage. Research Triangle Park, NC: GlaxoSmithKline;2007 March. Looking for medication to treat shingles? Acyclovir Dosing Advertisement. Acyclovir is an effective antiviral medication used primarily for treating the symptoms of herpes simplex virus infections, chickenpox, and shingles. If you think you have shingles, contact your healthcare provider as soon as possible to discuss treatment. These medicines are most effective if you start taking them as soon as possible after the rash appears.